Influence of AT1 Receptor Activity on AT1 and AT2 Receptor Expression During Fetal Life. † 284

Angiotensin II receptor subtypes AT1 and AT2 are down-regulated by angiotensin II through AT1 receptor by different mechanisms.

The regulatory effects of angiotensin II (AngII) on its receptor subtypes, AT1 and AT2, were studied using cultured bovine adrenal cells (BAC), which express both receptor subtypes, and PC12W and R3T3 cells, which express only AT2 receptors. In BAC, AngII caused a decrease in AT1- and AT2-binding sites and their corresponding messenger RNAs (mRNAs), but with different kinetics. AT1-binding site...

AT1 and AT2 receptor blockade and epinephrine release during insulin-induced hypoglycemia.

Angiotensin II facilitates epinephrine release during insulin-induced hypoglycemia, and this effect appears to be independent of type 1 angiotensin II (AT1) receptors in man. In the present study, we hypothesized that the action of angiotensin II on adrenomedullary epinephrine release is mediated by an AT2 receptor-dependent mechanism. In conscious chronically instrumented rats, we measured pla...

Chronic AT2 receptor activation attenuates renal AT1 receptor function and blood pressure in obese Zucker rats

Abnormal regulation of the renin angiotensin system such as enhanced renal AT1R function and reduced ACE2 activity contributes to obesity-related hypertension. Here, we tested whether long-term AT2R activation affects renal function in obesity using lean and obese Zucker rats treated with the AT2R agonist CGP42112A for 2 weeks. This caused blood pressure to decrease by 13 mm Hg, which was assoc...

AT1-receptor blockers

finding of elevated leptin levels in cardiac failure patients stage NYHA II or III is supported by Filippatos et al. and others. From their data, however, it appears that leptin levels tend to decrease in cachectic patients with more advanced stages of the disease, which has only recently been confirmed by others. This does not necessarily contradict our observations. The patients reported in o...

Myocardial salvage, AT1-receptor blockade, AT2-receptor activation and coronary collaterals.